How Fast Do You Lose Weight on Wegovy? What to Expect in the First 12 Weeks

If you’ve been exploring medically supported weight loss options, you’ve likely come across Ozempic. Originally licensed in the UK for the treatment of type 2 diabetes, Ozempic (semaglutide) has become widely known for its weight loss benefits, and it’s now a subject of much interest among patients struggling with obesity or long-term weight management.

At Junction Pharmacy in London, one of the most common questions we hear is: “How fast do you lose weight on Ozempic?” While the answer can vary from person to person, this post will walk you through what you can realistically expect in the first 12 weeks, what factors affect the rate of weight loss, and how we support our patients through the process.

What Is Ozempic and How Does It Work?

Ozempic is a once-weekly injection containing semaglutide, a medication that mimics the GLP-1 hormone naturally found in the body. This hormone plays a role in regulating blood sugar levels and slowing gastric emptying, which helps you feel fuller for longer.

For patients using Ozempic for weight loss, the benefits come from:

• –> Reduced appetite

• –> Lower overall calorie intake

• –> Improved blood sugar regulation

• –> A stronger sense of satiety after meals

Though Ozempic is not currently licensed in the UK specifically for weight loss, it is prescribed off-label or as Wegovy for eligible patients following a full medical assessment. Wegovy, which is a higher dose, has been licensed for weight management and is rolling out more widely.

How Fast Do You Lose Weight on Ozempic?

Weight loss with Ozempic tends to be gradual and steady, which is ideal for long-term sustainability. Clinical studies and real-world patient experiences show that most people begin noticing results within the first few weeks, but the pace can vary depending on dosage, lifestyle, and personal metabolism.

Here’s a general breakdown of what you might expect:

Weeks 1–4: Initial Adjustment

• –> You’ll typically start on a low dose (0.25mg) to help your body adjust

• –> This phase is about minimising side effects and building tolerance

• –> Weight loss may be modest, 0.5 to 2kg is common

• –> Some patients report reduced appetite almost immediately; others notice changes more gradually

Weeks 5–8: Increased Dosage and Appetite Control

• –> The dose is usually increased to 0.5mg or 1mg, depending on your progress and tolerance

• –> Appetite suppression becomes more noticeable at this stage

• –> Many patients lose an additional 1 to 3kg during this period

• –> You may also experience fewer cravings and naturally smaller portions

Weeks 9–12: Steady Weight Loss

• –> With regular use and good dietary habits, most patients start to see consistent weekly weight loss

• –> By 12 weeks, it’s not uncommon to have lost 5–7% of your starting body weight

• –> For someone weighing 90kg, that could mean 4.5–6kg lost in three months

Keep in mind, that these figures are averages – some people lose more, others less, and individual results depend on how well healthy lifestyle changes support the medication.

What Affects the Speed of Weight Loss?

While Ozempic can be an effective tool, it’s not a magic injection. Several factors influence how fast and how much weight you lose, including:

Starting weight – Heavier individuals may lose more weight initially

Diet and portion control – Ozempic helps reduce hunger, but the quality of food still matters

Physical activity – Adding regular movement boosts fat loss and supports muscle retention

Stress and sleep – High cortisol levels and poor sleep can slow weight loss

Underlying health conditions – Conditions like PCOS or thyroid issues may affect results

At Junction Pharmacy, we assess all of these areas as part of your initial consultation and continue monitoring them throughout your journey.

Are There Side Effects?

Like all medications, Ozempic can cause side effects. These most commonly include:

• –> Nausea

• –> Constipation or diarrhoea

• –> Bloating

• –> Fatigue

• –> Headache

These usually subside as your body adjusts. Our clinic provides detailed guidance on managing side effects and adjusting doses safely.

How Junction Pharmacy in London Supports You

At Junction Pharmacy, we offer medically led weight loss consultations that go beyond just handing out a prescription. We take time to understand your health background, goals, and lifestyle before offering tailored advice.

Our services include:

• –> Full eligibility assessment and medical screening

• –> Semaglutide, or Tirzepatide prescriptions (if clinically appropriate)

• –> Ongoing check-ins and support with dose adjustments

• –> Nutritional advice and portion control tips

• –> Support with side effect management and long-term maintenance planning

We believe that lasting weight loss comes from a personalised and supported approach – and we’re proud to offer that right here in London.

How Fast Will I Lose Weight on Semaglutide?

So, how fast do you lose weight on Ozempic? Most patients see steady, manageable weight loss over the first 12 weeks, especially when they combine the medication with healthy eating, movement, and consistent support.

If you’re struggling to lose weight despite your best efforts, semaglutide may be a helpful option, but it’s only part of the picture. At Junction Pharmacy in London, we’re here to support you through every step of your weight loss journey.

Contact us or drop in to book your consultation today and let us help you take the first step towards a healthier, more confident future.

This blog was written on behalf of Junction Pharmacy by Pharmacy Mentor.